Department of Personalized and Molecular Medicine

The department was established in 2019 with the aim of better patient care by providing early diagnosis, risk assessments, better prognosis and planning optimal treatment. The Department takes into account the individual pattern of genomics, dietary and environmental factors for the prevention, prediction, diagnosis and prognosis of disease and planning appropriate individualized treatment modalities thereby improving patient health care while also making it cost effective.

Mission:

• -To provide high quality cutting-edge research and training in interdisciplinary science for better understanding of the molecular mechanisms of human diseases and their management.
• - To translate the knowledge into innovative tools for the prevention, prediction, diagnosis and prognosis of disease and planning appropriate individualized treatment modalities thereby improving cost effective patient health.
• - To establishing national and international collaborations.

Vision:

• -To articulate and lead in the evolving areas of personalized and translational research and develop into a world-class teaching, training, research and patient care entity.

Postgraduate Certificate Course in Personalized and Molecular Medicine

(Course duration: 6 Month's; Fee Rs. 10,000/-).(Personalized and-Molecular Medicine) 
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Eligibility:
Candidate must have Ph.D/MD/M.Sc. in Biochemistry, Bioinformatics, Biotechnology, Botany, Pathology, M. Pharm, Chemistry, Environmental Science, Genetics, Mathematics, Medical Lab Technology, Microbiology, Veterinary Sciences, Zoology or M. Tech in Biotechnology/Bio-medical as one of the Subject(s) and with a minimum aggregate of 55% marks in degree or any other equivalent examination approved by UGC/ICMR.

Selection Criteria:
On the basis of a personal interview conducted by the ERA University.

Seats:
For every academic year only 20 Fellows shall be admitted.

Ph.D in Personalized & Molecular Medicine

(Course duration: Minimum 3.5 years; Annual Fee Rs. 50,000/-)

Eligibility:
The candidate must have passed post graduate in any branch of Life Sciences/MD with a minimum of 60% marks.

Selection Criteria:
Selection on the basis of entrance examination and Interview.

Laboratory:
The department has well-equipped laboratory with state-of-the-art facilities such as Sanger Sequencer, LCMS, UHPLC, Flow Cytometer, Real Time PCR, Gradient Thermal Cycler, Nanodrop, ELISA Reader, Inverted Microscope, Deep Freezer, Gel documentation system, Gel Electrophoresis Units, Cooling Centrifuge, PH meter, Distillation Unit, Autoclave, Laminar flow, Table Top Cooling Centrifuge, Rota Vapour, Incubator, Ice Flaker, Milli Q Apparatus & Weighing Balance, etc.

Computer Centre:
The Department has state-of-the-art computing facilities.

Library:
The department has well equipped library. Students also have access to central library which is well-equipped with the latest in reference books, periodicals, journals and newspapers. In addition university has facility of electronic library where holdings of the library are available in electronic format, and the services of the library are also made available over the Internet so that users can access them remotely.

Seminar Room:
The Department has seminar cum demo rooms for departmental presentations and meetings.

The department with the aim to ENSURE BETTER PATIENT CARE by enabling each patient to receive early diagnosis, risk assessments, and optimal treatment is working on genetic, pharmaco-genetic, dietary, environmental, and metabolic aspects of individual patient in different diseases. This department is currently working on various diseases such as Type 2 diabetes, gestational diabetes, polycystic ovarian syndrome (PCOS), cardiovascular diseases, osteoarthritis, celiac disease, breast cancer, chronic myeloid leukemia, neurodegenerative diseases, cervical cancer etc. The Department has well trained team of faculty members who are involved in both intramural and extramural research projects funded by ICMR, DBT, DST, CST-UP etc. and holds publications in various indexed national and international journals endorsing the exemplary research work carried out in the department.

RESEARCH AREAS

• Type 2 Diabetes
• Gestational Diabetes
• Polycystic Ovarian Syndrome (PCOS)
• Cardiovascular Diseases
• Osteoarthritis
• Celiac Disease
• Breast Cancer
• Chronic Myeloid Leukemia
• Neurodegenerative Diseases
• Cervical Cancer
• COVID-19
• Glaucoma

GENETIC PANELS (DIAGNOSTICS)
The Department is currently working on some genetic markers for better treatment management of diseases.
The panels are:

• CYP2C19 Genotyping
• VKORC & CYP2C9 Genotyping
• SLCO1B1 & ABCG2 Genotyping

PUBLICATIONS
RESEARCH PAPERS

1. Ansari AI, Rizvi AA, Verma S, et al. Interactions between diabetic and hypertensive drugs: a pharmacogenetics approach. Mol Genet Genomics. 2023;298(4):803-812. doi:10.1007/s00438-023-02011-7.
2. Abbas M, Verma S, Verma S, Siddiqui S, Khan FH, Raza ST, Siddiqi Z, Eba A, Mahdi F. Association of GSTM1 and GSTT1 gene polymorphisms with COVID‐19 susceptibility and its outcome. Journal of Medical Virology. 2021 Sep;93(9):5446-51.
3. Verma S, Abbas M, Verma S, Khan FH, Raza ST, Siddiqi Z, Ahmad I, Mahdi F. Impact of I/D polymorphism of angiotensin-converting enzyme 1 (ACE1) gene on the severity of COVID-19 patients. Infection, Genetics and Evolution. 2021 Jul 1;91:104801.
4. Verma S, Verma S, Khan FH, Siddiqi Z, Raza ST, Abbas M, Mahdi F. Genetic polymorphisms of IL6 gene –174G> C and –597G> A are associated with the risk of COVID‐19 severity. International Journal of Immunogenetics. 2022 Nov 2.
5. Verma S, Abbas M, Verma S, Raza ST, Mahdi F. the 2019 Novel pandemic of Coronavirus disease (COVID-19): a study of existing evidence in the Indian population. Era's Journal of Medical Research. 2020 Jul 1;7(2):199-204.
6. Verma S, Srivastava N, Banerjee M. Genetic polymorphisms in TCF7L2 and PPARG genes and susceptibility to Type 2 diabetes mellitus. Meta Gene. 2021 Jun 1;28:100864.
7. Verma S, Abbas M, Verma S, Abbas Rizvi A, Khan A, Tasleem Raza S, Mahdi F. A perspective of precision medicine in the management of COVID-19. Novel Research in Microbiology Journal. 2021 Aug 1;5(4):1313-24.
8. Verma S, Abbas M, Verma S, Abbas Rizvi A, Khan A, Tasleem Raza S, Mahdi F. Effectiveness of Blood Pressure and Body Temperature Screening for Severity in COVID-19 Patients. Journal of Microbiology and Infectious Diseases. 2021; 11 (3):147-151.
9. Abbas M, Mehdi A, Khan FH, Verma S, Ahmad A, Khatoon F, Raza ST, Afreen S, Glynn SA, Mahdi F. Role of miRNAs in cervical cancer: A comprehensive novel approach from pathogenesis to therapy. Journal of Gynecology Obstetrics and Human Reproduction. 2021 Nov 1;50(9):102159.
10. Verma S, Verma S, Abbas M, Rizvi AA, Khan A, Raza ST, Mahdi F. Role of Personalized Medicine in Thyroid Cancer: latest aspects. Era's Journal of Medical Research. 2021;8(1):76-81.
11. Verma S., Abbas M., Verma S., Rizvi AA., Khan A., Raza ST., Mahdi F. Risk of Mucormycosis in COVID-19 Patients: A Review. Era J. Med. Res. 2021; 8(2): 1-5.
12. Rizvi AA, Abbas M, Verma S, Verma S, Khan A, Raza ST, Mahdi F. Determinants in Tailoring Antidiabetic Therapies: A Personalized Approach. Global Medical Genetics. 2022 Jan 21.
13. Khan A, Abbas M, Verma S, Verma S, Rizvi AA, Haider F, Raza ST, Mahdi F. Genetic Variants and Drug Efficacy in Tuberculosis: A Step Toward Personalized Therapy. Global Medical Genetics. 2022 Feb 25.
14. Shoeb, Fouzia, Farzana Mahdi, and Imran Hussain. "Gender Differences Associated with Hyper-Inflammatory Conditions in COVID-19 Patients." (2022).
15. Rizvi S, Rizvi SM, Raza ST, Abbas M, Fatima K, Zaidi ZH, Mahdi F. Implication of single nucleotide polymorphisms in Interleukin-10 gene (rs1800896 and rs1800872) with severity of COVID-19. Egyptian Journal of Medical Human Genetics. 2022 Dec;23(1):1-8.
16. Mahdi RA, Ahmad I, Jilani T, Ansari JA, Mahdi F, Mahdi AA, Jafar T. Dopamine Gene Polymorphism, Biochemical and Oxidative Stress Parameters in Geriatric Population with and Without Depression: A Pilot Study. Indian Journal of Clinical Biochemistry. 2022 Jan;37(1):69-76.
17. Ansari O, Mahdi F., Jafar T., Ahmad I. Personalized medicine future perspective approach for the diagnosis of tuberculosis. Era’s Journal of Medical Research.2021:8(2);1-7.
18. Siddiqui S, Zia Q, Abbas M, Verma S, Jafri A, Misra D, Luqman S, Ahamed M, Ahmad MS, Arshad M. Antiproliferative activity of Cissus quadrangularis L. extract against human cervical cancer cells: in vitro and in silico analysis. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents). 2021 Dec 1;21(18):2536-45.
19. Ansari, O., Hussain, I., Jafar, T., Mahdi, F., & Ahmad, I. (2022). Pharmacogenomics for Infectious Diseases.
20. S. Mohd. Shiraz Rizvi, Farzana Mahdi, Abbas Ali Mahdi, Tabrez Jafar, Saliha Rizvi. Personalized medicine: role of asymmetric dimethylarginine as a predictive marker of cad. Era’s Journal of Medical Research. Vol 7 no. 1.2020 (Peer Reviewed).

BOOK CHAPTERS

1. Shrikant Verma, Mohammad Abbas, Sushma Verma and Farzana Mahdi. Impact of COVID-19 on environment. Trends in environmental biology. Kripa-Drisht Publication. ISBN:978-93-90847-55-6, Page No. 111-118.
2. Shrikant Verma, Mohammad Abbas, Sushma Verma and Farzana Mahdi. Impact of the COVID-19 pandemic on tuberculosis management. Impact and response (X). Bhumi Publishing. ISBN: 978-93-91768-46-1. Page no. 209-218.
3. Shrikant Verma, Mohammad Abbas, Sushma Verma and Farzana Mahdi. Post-COVID complications in COVID-19 patients. Impact and response (XII). Bhumi Publishing. ISBN: 978-93-91768-95-9. Page no. 29-41.

Indian Society of Personalized Medicine(Regd.) has been established with the aim to disseminate knowledge and promote research and academic excellence in the field of personalized medicine. The society has been registered under Societies Act 21,1860 of Goverment of India with Registration No. LUC/05821/2020-2021. The society is being formed with the vision, keen interest and efforts of several clinicians, scientists from India and abroad.

Inauguration

3rd International Conference on Personalized Medicine “REDEFINING THE FUTURE OF MEDICINE”- 25th -26th February 2023

NAMS-Sponsored Hands-On Workshop on Sanger Sequencing - 23rd-24th February 2023

International Symposium on Personalized Medicine “Newer Trends in Cardiovascular Research” & Hands-on Work Shop on Molecular Biology Techniques Including CRISPR/Cas9 Based Gene Editing held on 24th June 2022.

Hands-on Workshop on “Basic and Advanced Molecular Biology Techniques” Held o 30 th-31st March 2022

2^nd International Conference on Personalized Medicine: “Recent Advances and Challenges” Held on 24th -25th March 2021.

1^st International Conference on Personalized Medicine: “Concept and Role Players” Held on 19th -20th February 2020.

• Department of Surgical Oncology, King George's Medical University, Lucknow.
• Department of Radiation Oncology, King George's Medical University, Lucknow.
• Department of Medicine, Era’s Lucknow Medical College and Hospital, Era University, Lucknow.
• Department of Gynecology, Era’s Lucknow Medical College and Hospital, Era University, Lucknow.
• Department of Ophthalmology, Era’s Lucknow Medical College and Hospital, Era University, Lucknow.
• Department of Dentistry, Era’s Lucknow Medical College and Hospital, Era University, Lucknow.
• School of Medicine, National University of Irland Galway (NUIG), Galway, Irland.
• Department of Pulmonary Medicine, Era’s Lucknow Medical College and Hospital, Era University, Lucknow.